光热治疗
三磷酸腺苷
光敏剂
氧化磷酸化
化学
热休克蛋白
磷酸化
热休克蛋白27
光动力疗法
细胞生物学
生物物理学
生物
纳米技术
材料科学
生物化学
热休克蛋白70
光化学
有机化学
基因
作者
Qian Du,Xiaohan Qin,Mengzhu Zhang,Zhipeng Zhao,Qian Li,Xiaomeng Ren,Ningning Wang,Yuxia Luan
摘要
The oxidative phosphorylation inhibitor atovaquone (ATO) and the photosensitizer new indocyanine green (IR820) were self-assembled into carrier-free nanodrugs (IR820/ATO NPs) to achieve superior photothermal therapy (PTT), offering an attractive mitochondrial metabolism-regulatable approach for breast cancer treatment, where adenosine triphosphate (ATP) was downregulated along with downregulating the expression of heat shock proteins (HSPs) to amplify the sensitivity of PTT.
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