医学
骨形态发生蛋白
BMPR2型
失调家庭
肺动脉高压
心脏病学
信号转导
骨形态发生蛋白受体
内科学
内分泌学
细胞生物学
生物
遗传学
临床心理学
基因
作者
Marc Humbert,Vallerie V. McLaughlin,J. Simon R. Gibbs,Mardi Gomberg‐Maitland,Marius M. Hoeper,Ioana R. Preston,Rogério Souza,Aaron B. Waxman,Pilar Escribano,Jeremy Feldman,G. Meyer,David Montani,Karen M. Olsson,Solaiappan Manimaran,Jennifer Barnes,Peter G. Linde,Janethe de Oliveira Pena,David B. Badesch
标识
DOI:10.1056/nejmoa2024277
摘要
Pulmonary arterial hypertension is characterized by pulmonary vascular remodeling, cellular proliferation, and poor long-term outcomes. Dysfunctional bone morphogenetic protein pathway signaling is associated with both hereditary and idiopathic subtypes. Sotatercept, a novel fusion protein, binds activins and growth differentiation factors in the attempt to restore balance between growth-promoting and growth-inhibiting signaling pathways.
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