衰老
医学
病理
发病机制
缺血
肾
肾缺血
癌症研究
内科学
生物
急性肾损伤
再灌注损伤
作者
Seo Rin Kim,Amrutesh S. Puranik,Kai Jiang,Xiaojun Chen,Xiangyang Zhu,Ian Taylor,Alireza Khodadadi‐Jamayran,Amir Lerman,LaTonya J. Hickson,Bennett G. Childs,Stephen C. Textor,Tamar Tchkonia,Timothy B. Niewold,James L. Kirkland,Lilach O. Lerman
标识
DOI:10.1681/asn.2020091373
摘要
Maladaptive tubular cell senescence, involving upregulated p16 (Cdkn2a), p19 (Cdkn2d), and p21 (Cdkn1a) expression, is associated with renal dysfunction and injury in chronic ischemia. These findings support development of senolytic strategies to delay chronic ischemic renal injury.
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