色氨酸
戒指(化学)
生物有机化学
化学
组合化学
肽
氨基酸
立体化学
有机化学
生物化学
酶
作者
Jianlin Han,Nataliya V. Lyutenko,Alexander E. Sorochinsky,Ayaka Okawara,Hiroyuki Konno,S.W. White,Vadim A. Soloshonok
标识
DOI:10.1002/chem.202102485
摘要
Over the recent years there has been a noticeable upsurge of interest in aza-analogs of tryptophan which are isosteric to the latter and found numerous applications in medicinal, bioorganic chemistry, and peptide research. In the present review article, five aza-tryptophan derivatives are profiled, including aza-substitution in the positions 2, on the five-membered ring, as well as in positions 4, 5, 6, and 7 on the six-membered ring. A detailed and comprehensive literature overview of the synthetic methods for the preparation of these aza-tryptophans is presented and general facets of the biological properties and most promising applications are discussed.
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