碘伏
聚乙烯醇
自愈水凝胶
碘
材料科学
金黄色葡萄球菌
伤口愈合
生物医学工程
化学
高分子化学
细菌
医学
外科
复合材料
有机化学
生物
遗传学
作者
Zhaohua Miao,Y. K. Sun,Zhenchao Tao,Yu Chen,Yan Ma,Dongdong Zhu,Xiang Huang,Zhengbao Zha
标识
DOI:10.1002/adhm.202100722
摘要
Abstract Iodophor (povidone‐iodine) has been widely used for antibacterial applications in the clinic. Yet, limited progress in the field of iodine‐based bactericides has been achieved since the invention of iodophor. Herein, a blue polyvinyl alcohol‐iodine (PAI) complex‐based antibacterial hydrogel is explored as a new generation of biocompatible iodine‐based bactericides. The obtained PAI hydrogel maintains laser triggered liquefaction, thermochromic, and photothermal features for highly efficient elimination of bacteria. In vitro antibacterial test reveals that the relative bacteria viabilities of Escherichia coli (E.coli) and methicillin‐resistant Staphylococcus aureus (MRSA) incubated with PAI hydrogel are only 8% and 3.8%, respectively. Upon single injection of the PAI hydrogel, MRSA‐infected open wounds can be efficiently healed in only 5 days, and the healing speed is further accelerated by laser irradiation due to the dynamic interaction between iodine and polyvinyl alcohol, causing up to ∼29% of wound area being closed on day 1. In addition, a safe threshold temperature of skin scald (∼45 °C) emerges for PAI hydrogels because of thermochromic properties, avoiding thermal injuries during irradiation. In addition, no observed toxicity or skin irritation is observed for the PAI hydrogel. This work expands the category of iodine‐based bactericides for safe and controllable management of infected wounds.
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