软骨藻酸
分子印迹聚合物
化学
检出限
石墨烯
聚丙烯酰胺
色谱法
纳米技术
毒素
有机化学
选择性
材料科学
高分子化学
生物化学
催化作用
作者
Meihui Jiang,Junyan Tang,Nuoyi Zhou,Juan Liu,Feifei Tao,Fei Wang,Caolong Li
出处
期刊:Talanta
[Elsevier]
日期:2022-01-01
卷期号:236: 122885-122885
被引量:7
标识
DOI:10.1016/j.talanta.2021.122885
摘要
Domoic acid, namely amnesic shellfish toxin, is a highly neurotoxic substance to marine animals and humankind. To reduce the incidence of poisoning accidents, the exploitation of specific and rapid detection method for domoic acid monitoring is highly required. Herein, an electrochemical molecularly imprinted polymer (MIP) sensor based on polydopamine-reduced graphene oxide/polyacrylamide composite (PDA-rGO/PAM) was constructed successfully to detect domoic acid. The domoic acid molecule could be recognized in imprinted cavities of PAM reversibly through hydrogen bonding. PDA-rGO promoted the loading capacity of PAM and improved the charge transfer rate, which amplified the electrical signal response of the MIP sensor. The screen-printed electrode (SPE) modified with PDA-rGO/PAM displayed satisfactory response toward toxin contaminated sample at a linear range from 1 to 600 nM and a low detection limit of 0.31 nM, demonstrating the prospective application of the transducer as a portable sensing platform for the on-site detection of hazardous marine biotoxin. Moreover, benefiting from the superior specificity and stability of MIP, the fabricated sensor could be utilized to detect the domoic acid content in mussel extracts directly without complex pretreatment operation.
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