生物
细胞外基质
转移
生态位
利基
神经科学
癌症
细胞生物学
生态学
遗传学
栖息地
作者
Sarah K. Deasy,Neta Erez
标识
DOI:10.1016/j.tcb.2021.08.001
摘要
Modification of the extracellular matrix (ECM) is a critical aspect of developing a metastasis-supportive organ niche. Recent work investigating ECM changes that facilitate metastasis has revealed ways in which different metastatic organ niches are similar as well as the distinct characteristics that make them unique. In this review, we present recent findings regarding how ECM modifications support metastasis in four frequent metastatic sites: the lung, liver, bone, and brain. We discuss ways in which these modifications are shared between metastatic organs as well as features specific to each location. We also discuss areas of technical innovation that could be advantageous to future research and areas of inquiry that merit further investigation.
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