重组因子VIIa
医学
因素七
血友病
因子VIIa
血友病A
置信区间
重组DNA
内科学
药理学
组织因子
凝结
外科
生物化学
化学
基因
作者
Ana Rosa Cid,José Ignacio Lorenzo,Saturnino Haya,Juan Montoro,Pilar Casaña,José A. Aznar
出处
期刊:Haemophilia
[Wiley]
日期:2001-01-01
卷期号:7 (1): 39-41
被引量:20
标识
DOI:10.1046/j.1365-2516.2001.00478.x
摘要
The use of recombinant factor VIIa (rFVIIa) is on the increase, not only to treat haemophilic patients with inhibitors, but also patients with other clotting disorders. However, the most appropriate method of monitoring this treatment remains a question that has yet to be resolved. We studied 24 plasma samples from patients receiving rFVIIa treatment (three had haemophilia A with inhibitors, and three a congenital FVII deficiency) and compared the results obtained from the FVII:C and FVIIa assays. Although a good correlation between the two methods was obtained (r = 0.91), the values of the FVII:C method were 1.63 higher than those of the FVIIa method, with a relatively wide margin in the interval of the FVII:C/FVIIa ratios obtained [95% confidence interval (CI) 1.38--1.88, range 0.68--3.68]. This interval became wider when we compared values of over 6 IU mL(-1), which led us to conclude that the two methods cannot be considered equivalent. As the FVIIa method specifically measures FVIIa, and FVII:C assay is known to have a wide interlaboratory variability, we believe that the FVIIa assay would be more suitable for the monitoring of rFVIIa treatment.
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