化学
糖原磷酸化酶
萜烯
化学合成
生物化学
立体化学
酶
体外
作者
Xiaoan Wen,Pu Zhang,Jun Li,Luyong Zhang,Xiaoming Wu,Pei‐Zhou Ni,Hongbin Sun
标识
DOI:10.1016/j.bmcl.2005.10.014
摘要
The synthesis of a series of maslinic acid derivatives is described and their effect on rabbit muscle glycogen phosphorylase a evaluated. Within this series of compounds, 15 (IC50 = 7 μM) is the most potent GPa inhibitor. SAR of the maslinic acid derivatives are discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI