化学
立体选择性
部分
赫克反应
立体化学
片段(逻辑)
烯烃纤维
格氏反应
全合成
缩合反应
有机化学
催化作用
钯
试剂
计算机科学
程序设计语言
作者
M. V. Rao,B. Venkateswara Rao,Bokka Ramesh
标识
DOI:10.1016/j.tetlet.2014.09.009
摘要
A new stereoselective approach for the synthesis of AI-77-B has been described. Dihydroisocoumarin fragment was made in two routes using Heck reaction followed by oxidation of the olefin and LDA mediated reaction. The chiral amino acid moiety has been obtained from d-ribose involving Grignard reaction on ribosylimine. Finally, condensation of dihydroisocoumarin with acid fragment furnished the title target AI-77-B.
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