Abstract The polyoxometalate K 6 H[CoW 11 O 39 (CpTi)] (abbreviated as CoW 11 CpTi, Cp= η 5 ‐C 5 H 5 ) loaded nanosize‐liposome complex has been prepared and structurally characterized by elemental analysis, IR and UV spectra. The particle size of the complex was distributed in the range of 100–250 nm with the average diameter of 132.6 nm. The result showed that the polyoxometalate retained the parent structure after being encapsulated by liposome and liposomal encapsulation increased the antitumoral activity of the polyoxometalate.