A mechanism for salt-sensitive hypertension: abnormal dietary sodium-mediated vascular response to angiotensin-II

Hypertensive individuals have an abnormal vascular response to ANGII infusion on a high-salt diet. Dysregulated tissue renin-angiotensin system activity may play a role in this abnormal response. These findings raise an intriguing novel possibility for the pathophysiologic mechanism of salt-sensitive hypertension.