对映选择合成
化学
非对映体
内酯
对映体
立体化学
催化作用
有机化学
作者
B. Loubinoux,Jean-Luc Sinnes,Anthony C. O’Sullivan,Tammo Winkler
出处
期刊:Tetrahedron
[Elsevier]
日期:1995-03-01
卷期号:51 (12): 3549-3558
被引量:36
标识
DOI:10.1016/0040-4020(95)00098-s
摘要
The compound 2 comprises a southern-half subunit of the fungicidal macrolide soraphen A 1. It was prepared by a Meinwald reaction of the enolate of S-7 with the lactone S-8. Its enantiomer and diastereomers were synthesized in a similar manner. The lactone S-8 and its enantiomer R-8 were prepared by three different routes, including the enantioselective catalytic reduction of the β-keto ester 17. These lactones are new and potentially useful as C-5 asymmetric building blocks.
科研通智能强力驱动
Strongly Powered by AbleSci AI