分子印迹聚合物
可替宁
色谱法
聚合物
萃取(化学)
固相萃取
傅里叶变换红外光谱
化学
聚合
沉淀聚合
吸附
热重分析
材料科学
化学工程
自由基聚合
有机化学
选择性
尼古丁
医学
内科学
工程类
催化作用
作者
Haley A Mulder,Thomas I Cecil,Cory B. Fines,Adam C. Pearcy,Matthew S. Halquist
出处
期刊:Bioanalysis
[Newlands Press Ltd]
日期:2023-04-01
卷期号:15 (8): 465-477
被引量:1
标识
DOI:10.4155/bio-2023-0019
摘要
Aim: To characterize a molecularly imprinted polymer via precipitation polymerization for the extraction of cotinine in urine. Methods: The polymer was created via precipitation polymerization. Physical characteristics of the polymer were assessed via scanning electron microscopy, Fourier transform infrared spectroscopy and thermogravimetric analysis. The polymer adsorption capacity was assessed and an solid-phase extraction method from urine by LC-MS/MS was developed. Results: The polymer had small, spherical morphology and little thermal decomposition. The extraction method yielded cotinine recoveries of 77-103% in urine. The molecularly imprinted polymer adsorption capacity for cotinine was 448.2 ± 2.1 μg/mg. Common interferants did not affect cotinine's extraction. Conclusion: The resulting polymer was determined to be specific for cotinine and can be used for the detection of cotinine in urine for clinical samples.
科研通智能强力驱动
Strongly Powered by AbleSci AI