Double-layered PLGA/HA microneedle systems as a long-acting formulation of polyphenols for effective and long-term management of atopic dermatitis

Co-delivery of curcumin (CUR) and gallic acid (GA) using the double-layered PLGA/HA microneedles can exhibit synergistic antioxidant and anti-inflammatory effects for rapid and long-lasting relief of atopic dermatitis symptoms in Nc/Nga mice.