光动力疗法
磁共振成像
材料科学
体内
活性氧
纳米技术
化学
医学
放射科
生物技术
有机化学
生物
生物化学
作者
Yining Tao,Chenxu Yan,Yue Wu,Dan Li,Juan Li,Yuchen Xie,Ying-Sheng Cheng,Yisheng Xu,Kai Yang,Weihong Zhu,Zhiqian Guo
标识
DOI:10.1002/adfm.202303240
摘要
Abstract Unpredictable in vivo therapeutic feedback of reactive oxygen species (ROS) efficiency is the major bottleneck of photodynamic therapy (PDT). Herein, novel PDT‐based nanotheranostics Pa–Mn&CH‐A@P are elaborately constructed for in vivo tracking biodistribution and in situ self‐reporting PDT, which innovatively unites magnetic resonance imaging (MRI) and chemiluminescence (CL) signals. Taking advantages of the versatility of lanthanide coordination chemistry and flash nanoprecipitation (FNP) technology, photosensitizers, MRI, and CL agents are unprecedently integrated within a stable and uniform nanotheranostic. Specifically, MRI signal offers detailed dose distribution of nanotheranostics with high‐spatial resolution, and CL signal timely performs in situ evaluation of ROS generation with high sensitivity. This dual‐modal MRI/CL nanotheranostic makes a breakthrough in high fidelity feedback for oral tumor, conquering the inherent unpredictable obstacles on spatially and sensitively reporting PDT.
科研通智能强力驱动
Strongly Powered by AbleSci AI