成纤维细胞
伤口愈合
生物
胚胎干细胞
电池类型
细胞生物学
细胞
生物信息学
免疫学
细胞培养
遗传学
基因
作者
Dongsheng Jiang,Ruiji Guo,Hans‐Günther Machens,Yuval Rinkevich
出处
期刊:Cold Spring Harbor Perspectives in Biology
[Cold Spring Harbor Laboratory]
日期:2022-09-27
卷期号:15 (3): a041222-a041222
被引量:12
标识
DOI:10.1101/cshperspect.a041222
摘要
Wound healing disorders are a societal, clinical, and healthcare burden and understanding and treating them is a major challenge. A particularly important cell type in the wound healing processes is the fibroblast. Fibroblasts are not homogenous; however, there are diverse functional fibroblast subtypes coming from different embryonic origins and residing in dispersed anatomic locations including distinct classes of fibroblasts at various skin depths. In this review, we discuss the implications of fibroblast heterogeneity, with a focus on the fundamental physiological functions of the fibroblast subtypes that govern wound repair and clinical degrees of healing. A better understanding of these diverse functional fibroblast populations will likely lead to novel therapies to enhance wound healing and inhibit excessive scarring.
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