神经干细胞
纳米医学
癌症研究
干细胞
移植
医学
下调和上调
细胞生物学
化学
纳米技术
内科学
材料科学
生物
纳米颗粒
生物化学
基因
作者
Zhe Wang,Yujun Cai,Qinyuan Zhang,Jianing Li,Bingling Lin,Junya Zhao,Fang Zhang,Yunhua Li,Xieqing Yang,Liejing Lu,Xintao Shuai,Jun Shen
标识
DOI:10.1002/adhm.202201630
摘要
Neural stem cells (NSCs) transplantation has been considered as a promising strategy for the treatment of ischemic stroke. However, the therapeutic prospect is limited by the poor control over the survival, migration, and maturation of transplanted NSCs. Upregulating hypoxia inducible factor (HIF)-1α expression in stem cells can improve the survival and migration of NSCs grafted for stroke therapy. Functional peptide drugs, which could inhibit endogenous HIF-1α ubiquitination, might be used to effectively upregulate the HIF-1α expression in NSCs, thereby to improve the therapeutic effect in ischemia stroke. Herein, a magnetic resonance imaging (MRI)-visible nanomedicine is developed to codeliver functional peptides and superparamagnetic iron oxide (SPIO) nanoparticles into NSCs. This nanomedicine not only promotes the survival and migration ability of NSCs but also allows an in vivo tracking of transplanted NSCs with MRI. The results demonstrate the great potential of the functional peptides-complexed multifunctional nanomedicine in boosting the therapeutic effect of stem cell-based therapy in stroke.
科研通智能强力驱动
Strongly Powered by AbleSci AI