光热治疗
钙
肿瘤微环境
生物相容性
生物物理学
医学
化学
癌症研究
材料科学
纳米技术
肿瘤细胞
生物
有机化学
作者
Wenliang Wang,Jing Yu,Lin Yang,Meng Li,Yi Pan,Yichen He,Longcai Liu,Xiao Meng,Zhenye Lv,Ketao Jin,Shenglei Che,Xiaozhou Mou,Chang Yeon Yu
出处
期刊:Biomaterials advances
日期:2023-06-01
卷期号:149: 213418-213418
被引量:3
标识
DOI:10.1016/j.bioadv.2023.213418
摘要
With excellent biocompatibility, stable chemical and optical properties, small organic molecules-based agents have always been a research hotspot in cancer photothermal therapy (PTT). In this work, a novel croconic acid-based molecule (CR) was designed and synthesized as an ideal photothermal agent (PTA), which showed abundant near-infrared (NIR) light absorption, high photothermal conversion ability, and excellent photothermal stability. By loading CR and quercetin (Qu) in CaO2, and coated with DSPE-PEG2000, a multifunctional theranostic nanoparticle (CCQ) was successfully prepared for calcium overloading mitochondrial metabolism inhibition synergetic mild PTT. Upon entering tumor microenvironment, CCQ can produce abundant H2O2 and a large amount of calcium ions, which lead to the imbalance of calcium concentration in the internal environment of tumor cells and induced mitochondrial apoptosis. With the existence of Qu, CCQ can effectively inhibit the expression of heat shock proteins (Hsp) during the PTT process, which weaken the heat resistance of tumors, ablate tumors at lower temperature (~45 °C), and reduce the damage to normal tissues. Guided by photoacoustic imaging (PAI), CCQ showed excellent multimodal therapeutic effect of tumors. This study provided a novel CR organic molecule-based theranostic nanoplatform that can be used to treat tumors via calcium overload therapy synergetic PTT at safe temperatures, which has promising potential for the future clinical cancer treatment.
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