IDH2 and GLUD1 Depletion Arrests Embryonic Development through an H4K20me3 Epigenetic Barrier in Porcine Parthenogenetic Embryos

Isocitrate dehydrogenase 2 (IDH2) and glutamate dehydrogenase 1 (GLUD1) are key enzymes involved in the production of α-ketoglutarate (α-KG), a metabolite central to the tricarboxylic acid cycle and glutamine metabolism. In this study, we investigated the impact of IDH2 and GLUD1 on early porcine embryonic development following