生殖毒性
苯并(a)芘
内分泌系统
发情周期
性成熟
少年
生物
男科
卵巢
生理学
毒性
肛门生殖距离
内科学
毛囊
内分泌学
激素
毒理
怀孕
医学
胎儿
子宫内
致癌物
遗传学
作者
Ana Carolina Casali Reis,Bárbara Campos Jorge,Beatriz Rizzo Paschoalini,Jéssica Nogueira Bueno,Júlia Stein,Suyane da Silva Moreira,Beatriz de Manoel Manoel,Glaura Scantamburlo Alves Fernandes,Hamilton Hisano,Arielle Cristina Arena
标识
DOI:10.1080/01480545.2022.2105864
摘要
Since studies on the reproductive consequences after the exposure to environmentally relevant doses of Benzo(a)pyrene (BaP) during critical stages of development are scarce, this study evaluated female reproductive parameters of adult rats exposed to a low dose of BaP during the juvenile phase. Female rats (Post-natal 21) were treated with BaP (0 or 0.1 µg/kg/day; gavage) for 21 consecutive days. During the treatment, no clinical signs of toxicity were observed. Nevertheless, the ages of vaginal opening and first estrus were anticipated by the BaP-exposure. At the sexual maturity, the juvenile exposure compromised the sexual behavior, as well as the placental efficiency, follicle stimulating hormone levels, placenta histological analysis, and ovarian follicle count. A decrease in erythrocyte, platelet, and lymphocyte counts also was observed in the exposed-females. Moreover, the dose of BaP used in this study was not able to produce estrogenic activity in vivo. These data showed that juvenile BaP-exposure, at environmentally relevant dose, compromised the female reproductive system, possibly by an endocrine deregulation; however, this requires further investigation.
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