Study on the Blood glucose Regulation function of Lactobacillus plantarum NXU0011 Powder

C57BL/6J mice were studied to evaluate the hypoglycemic function of bacterial powder. The results showed that the bacterial powder had good inhibition ability to α-amylase and α-glucosidase. After the intervention of bacterial powder in diabetic mice, the indexes of fasting blood glucose and insulin level were reduced, and glucose tolerance was improved; the histological results showed that: the alpha diversity of the bacterial powder group (HLP) was improved, and the Shannon index was higher than that of the blank group (CN), Bifidobacterium animaliss, Lactobacillus acidophilus and Akkermansia muciniphila were enriched and had significant differences. Compared with CN group, the expression levels of Hydroxyphenyllactic acid, L-2-Hydroxy-glutaric acid and Glutamic acid in HLP group were significantly increased. Meanwhile, Carbohydrate metabolism, Amino acid metabolism, Nucleotide metabolism and other related pathways were improved. In summary, the Lactobacillus plantarum NXU0011 powder alleviates diabetes by regulating the intestinal flora and metabolites of mice.