A Randomized Controlled Trial Comparing Methotrexate Iontophoresis and Oral Methotrexate for the Treatment of Hyperkeratotic Palmoplantar Eczema

BACKGROUND: Palmoplantar hyperkeratotic eczema is quite disabling and affects a person's daily quality of life. Among the various treatment options available, oral methotrexate was quite effective. However, it was associated with systemic and cutaneous side effects. Therefore, delivery of methotrexate through Iontophoresis was an option to reduce the adverse effects and to enhance the absorption and efficacy. OBJECTIVES: To observe the efficacy and the adverse effects of methotrexate iontophoresis as compared to oral methotrexate therapy in the treatment of hyperkeratotic palmoplantar eczema. METHODOLOGY: = 44, 50%) received oral methotrexate (7.5 mg/week) with gradual dose increases. Efficacy was assessed using Hand Eczema Severity Index (HECSI) scores, digital photography, and follow-up evaluations conducted three months after study completion. RESULTS: = 1) in Group B. CONCLUSIONS: Iontophoretic delivery of methotrexate in palmoplantar hyperkeratotic eczema was equally effective as oral methotrexate.