细菌粘附素
金念珠菌
殖民地化
毒力
微生物学
生物膜
生物
毒力因子
细菌
遗传学
基因
抗真菌
作者
Darian J. Santana,Juliet A. E. Anku,Guolei Zhao,Robert Żarnowski,Chad Johnson,Haley Hautau,Noelle D. Visser,Ashraf S. Ibrahim,David R. Andes,Jeniel E. Nett,Shakti Singh,Teresa R. O’Meara
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-09-29
卷期号:381 (6665): 1461-1467
被引量:15
标识
DOI:10.1126/science.adf8972
摘要
Candida auris is an emerging fungal pathogen responsible for health care–associated outbreaks that arise from persistent surface and skin colonization. We characterized the arsenal of adhesins used by C. auris and discovered an uncharacterized adhesin, Surface Colonization Factor (Scf1), and a conserved adhesin, Iff4109, that are essential for the colonization of inert surfaces and mammalian hosts. SCF1 is apparently specific to C. auris , and its expression mediates adhesion to inert and biological surfaces across isolates from all five clades. Unlike canonical fungal adhesins, which function through hydrophobic interactions, Scf1 relies on exposed cationic residues for surface association. SCF1 is required for C. auris biofilm formation, skin colonization, virulence in systemic infection, and colonization of inserted medical devices.
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