内体
脂肽
纳米颗粒
细胞生物学
肽
螺旋线圈
无规线圈
信使核糖核酸
脂质双层融合
生物
生物物理学
材料科学
化学
纳米技术
生物化学
细胞
基因
膜
蛋白质二级结构
遗传学
细菌
作者
Ye Zeng,Ming Shen,Roy Pattipeiluhu,Xuebing Zhou,Yun Zhang,Thomas Bakkum,Thomas H. Sharp,Aimee L. Boyle,Alexander Kros
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:15 (37): 15206-15218
被引量:3
摘要
Regular nanoparticles delivery efficiency is hindered by endosome entrapment. By modifying lipid-nanoparticles with lipopeptide CPE4 and pretreating the cells with complimentary CPK4, coiled-coil peptides induced significantly enhanced mRNA delivery in various cell lines mediated by membrane fusion.
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