Integrative serum proteomics analysis reveals distinct immune and cardiovascular profile dysregulation in erythrodermic psoriasis

In-depth analysis of circulating proteome alterations identified that erythrodermic psoriasis (EP) presented a dysregulated serum proteome with distinct inflammation elevation, immune activation and metabolic disturbance. We found that EP harboured a blended immune milieu with distinct T helper (Th)17/Th1 skewing and mild Th2 activation. Additionally, atherosclerosis signalling were substantially increased in EP.