结缔组织增生
胰腺癌
肿瘤微环境
缺氧(环境)
转移
血管生成
癌症研究
医学
免疫抑制
癌症
生物
内科学
化学
有机化学
氧气
作者
Huan Zhang,Kejiang Cao,Jingrong Xiang,Mengting Zhang,Mengxin Zhu,Qinhua Xi
出处
期刊:Cancer Letters
[Elsevier]
日期:2023-09-01
卷期号:571: 216345-216345
被引量:2
标识
DOI:10.1016/j.canlet.2023.216345
摘要
Pancreatic cancer is one of the common malignant tumors of the digestive system and is known as the "king of cancers". It is extremely difficult to diagnose at an early stage, the disease progresses rapidly, and the effect of chemotherapy and radiotherapy is poor, so the prognosis of pancreatic cancer patients is very poor. Numerous studies have suggested that hypoxia is closely related to the development and progression of pancreatic cancer. Inadequate blood supply and desmoplasia in the microenvironment of pancreatic cancer can result in its extreme hypoxia. This hypoxic microenvironment can further contribute to angiogenesis and desmoplasia. Hypoxia is mediated by the complex hypoxia inducible factor (HIF) signaling pathway and plays an important role in the formation of a highly immunosuppressive microenvironment and the metastasis of pancreatic cancer. Further work on the hypoxic microenvironment will help clarify the specific mechanisms of the role of hypoxia in pancreatic cancer and provide a basis for the realization of hypoxia-targeted therapeutic and diagnostic strategies.
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