Two new guaiane-type sesquiterpenes from Curcuma wenyujin

AbstractTwo new guaiane-type sesquiterpenes, wenyujinolides A (1) and B (2), were isolated from the ethanol extract of Curcuma wenyujin, together with 10 known compounds. Their structures were established by extensive spectroscopic methods (IR, ESIMS, HRESIMS, ECD, 1D and 2D NMR) and comparison of their NMR data with literatures. Compounds 1 and 2 were evaluated for the inhibition of NO production in LPS induced RAW 264.7 macrophages.Keywords: Curcuma wenyujinguaiane-type sesquiterpeneswenyujinolide Awenyujinolide B Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingThis work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China.