Cost-effectiveness and prognostic model of hepatic arterial infusion chemotherapy for hepatocellular carcinoma with high tumor burden and/or Vp4 tumor thrombus compared with sorafenib: a post-hoc analysis of the FOHAIC-1 trial

医学 肝细胞癌 索拉非尼 内科学 肿瘤科 放射性武器 成本效益 比例危险模型 放射科 外科 胃肠病学 风险分析(工程)
作者
Qifeng Chen,Ning Lyu,Xun Wang,Xiongying Jiang,Hu Yue,Song Chen,Sui‐Xing Zhong,Zilin Huang,Minshan Chen,Ming Zhao
出处
期刊:International Journal of Surgery [Elsevier]
卷期号:109 (12): 3929-3939 被引量:3
标识
DOI:10.1097/js9.0000000000000683
摘要

Objectives: The phase III FOHAIC-1 trial revealed that hepatic arterial infusion of chemotherapy (HAIC) improved overall survival compared to sorafenib in the high-risk hepatocellular carcinoma (HCC). This study therefore set out to evaluate the cost-effectiveness and establish a prognostic clinico-radiological score of HAIC. Materials and methods: A total of 409 patients with high-risk HCC who received HAIC between 2014 and 2020 were included. A Markov model was applied in the cost-effectiveness analysis using data from the FOHAIC-1 trial. In prognosis analysis, a clinico-radiological score was developed using a Cox-regression model and subsequently confirmed in the internal validation and test cohorts. The area under the curve from receiver operator characteristic analysis was used to assess the performance of the clinico-radiological score. Results: HAIC resulted in an incremental cost-effectiveness ratio of $10190.41/quality-adjusted life years compared to sorafenib, which was lower than the willingness-to-pay threshold. Probabilistic sensitivity analysis predicted a ≥99.9% probability that the incremental cost-effectiveness ratio was below the willingness-to-pay. The Cox analysis identified five factors, namely extrahepatic metastasis (m), arterial enhancing type (a), tumor number (nu), albumin-bilirubin index (a), and involved lobe (l), which together comprise the clinico-radiological score (HAIC-manual). Patients were classified into three groups based on the number of factors present, with cutoffs at 2 and 4 factors. The stratified median overall survival for these groups were 21.6, 10.0, and 5.9 months, respectively ( P <0.001). These findings were verified through internal validation and test cohorts with a significance level of P ≤0.01. The time-dependent area under the curve from receiver operator characteristic for the ability of the HAIC-manual to predict survival in 1, 2, and 3 years were 0.71, 0.76, and 0.78, which significantly outperformed existing staging systems. Conclusion: HAIC is a promising and cost-effective strategy for patients with high-risk HCC. The clinico-radiological score may be a simple prognostic tool for predicting HAIC treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
dhjic完成签到 ,获得积分10
4秒前
ken131完成签到 ,获得积分10
4秒前
yinyin完成签到 ,获得积分10
6秒前
希子完成签到 ,获得积分10
7秒前
jxwe完成签到 ,获得积分10
11秒前
蓝景轩辕完成签到 ,获得积分0
11秒前
小绵羊完成签到,获得积分20
15秒前
666星爷完成签到,获得积分10
15秒前
kk应助科研通管家采纳,获得10
16秒前
16秒前
天天快乐应助时尚东蒽采纳,获得10
19秒前
21秒前
明理丹烟应助philophysics采纳,获得10
23秒前
彩色的冷梅完成签到 ,获得积分10
30秒前
华夫饼完成签到 ,获得积分10
34秒前
34秒前
mia发布了新的文献求助10
35秒前
缓慢的甜瓜完成签到 ,获得积分10
35秒前
午午午午完成签到 ,获得积分10
36秒前
地狱跳跳虎完成签到 ,获得积分10
38秒前
40秒前
温婉的夏烟完成签到 ,获得积分10
41秒前
42秒前
5High_0完成签到 ,获得积分10
44秒前
时尚东蒽发布了新的文献求助10
48秒前
洁净青筠完成签到,获得积分10
54秒前
ommphey完成签到 ,获得积分10
55秒前
荔枝完成签到 ,获得积分10
1分钟前
木木杉完成签到 ,获得积分10
1分钟前
chenying完成签到 ,获得积分0
1分钟前
时尚东蒽完成签到,获得积分20
1分钟前
遇楹完成签到 ,获得积分10
1分钟前
内向南风完成签到 ,获得积分10
1分钟前
雷九万班完成签到 ,获得积分10
1分钟前
PM2555完成签到 ,获得积分10
1分钟前
单兰完成签到 ,获得积分10
1分钟前
竞鹤发布了新的文献求助10
1分钟前
mousehe完成签到,获得积分10
1分钟前
研友_ZA2B68完成签到,获得积分10
1分钟前
松子的ee完成签到 ,获得积分10
2分钟前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052652
求助须知:如何正确求助?哪些是违规求助? 2709874
关于积分的说明 7418298
捐赠科研通 2354492
什么是DOI,文献DOI怎么找? 1246104
科研通“疑难数据库(出版商)”最低求助积分说明 605951
版权声明 595921