免疫疗法
医学
免疫系统
肺癌
癌症疫苗
疫苗疗法
免疫学
癌症免疫疗法
新城疫
癌症
病毒
癌症研究
T细胞
抗原
免疫原性细胞死亡
病毒学
肿瘤科
内科学
作者
Hui Wang,Fulong Nan,Zhongmin Zhou,Xueming Zhang,Dingxin Ke,Shuyun Zhang,Xiaoqiong Zhou,Delei Niu,Tianyu Fan,Shasha Jiang,Xianjuan Zhang,Bin Wang,Wanming Zhang
摘要
Abstract Lung cancer is a fatal disease with the highest worldwide morbidity and mortality rates. Despite recent advances in targeted therapy and immune checkpoint inhibitors for cancer, their efficacy remained limited. Therefore, we designed a Newcastle disease virus (NDV)‐modified tumor whole‐cell vaccine as a therapeutic vaccine and identified its antigen presentation level to develop effective immunotherapy. Then, we calculated the therapeutic and immune‐stimulating effects of NDV‐modified lung cancer cell vaccine and intratumoral NDV injection combination on tumor‐bearing mice. The results showed that the immunogenic cell death (ICD) expression in NDV‐modified lung cancer cell vaccine stimulates dendritic cell maturation and T cell activation in vivo and in vitro. Moreover, NDV‐modified lung cancer cell vaccine combined with intratumoral NDV injection could significantly inhibit tumor growth and enhance the differentiation of Th1 cells and Inflammatory cell infiltration in vivo, leading to an excellent immunotherapeutic effect. Therefore, our results revealed that NDV‐modified lung cancer cell vaccine combined with intratumoral NDV injection could promote antigen presentation and induce a strong antitumor immune response, which provided a promising combined therapy strategy for tumor immunotherapy.
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