Synergistic phototherapy and Ca2+ consumption for combating biofilms in diabetic wounds via ion interference, physical disruption, and biological regulation

critical signaling pathways. This work proposes a multimodal therapy strategy by integrating ion interference-physical disruption-biological regulation into a single platform, offering a new paradigm for combating biofilms infected diabetic wounds while actively promoting tissue regeneration. Such a concept not only expands the potential of light-driven therapies in infected-wound care but also provides a blueprint for next-generation multifunctional materials through synergistic and programmable interactions.