化学
熊果酸
齐墩果酸
Zeta电位
纳米颗粒
多糖
氢键
核化学
生物化学
色谱法
分子
有机化学
纳米技术
材料科学
替代医学
病理
医学
作者
Shanshan Zhu,Zhichang Qiu,Xuguang Qiao,Geoffrey I.N. Waterhouse,Wei Zhu,Wenting Zhao,Qiuxia He,Zhenjia Zheng
标识
DOI:10.1016/j.fshw.2022.07.047
摘要
This study explored the potential of polysaccharides from Actium lappa (ALPs) as natural wall materials for producing ALP-based nanoparticles to deliver poorly water-soluble oleanolic acid (OA) and ursolic acid (UA). Encapsulating OA+UA with ALPs (ALP:OA+UA, 50:1; OA:UA, 1:1) changed the crystalline nature to a more amorphous state through hydrogen bonding and involving O–H/C–O/O–C–O groups. ALP-OA/UA nanoparticles had a particle size and zeta potential (in water) of 199.1 nm/–7.15 mV, with a narrow unimodal size distribution, and excellent pH, salt solution, temperature and storage stability. Compared with ALPs, ALP-OA/UA nanoparticles showed enhanced anti-inflammatory activity (especially at a dose of 100 μg/mL) in a CuSO4-induced zebrafish inflammation model via down-regulating the NF-κB signalling pathway and gene expression of associated transcription factors and cytokines (TNF-α, IL-1β and IL-8). Therefore, ALP-based nanoparticles are natural and anti-inflammatory carriers for hydrophobic bioactive molecules.
科研通智能强力驱动
Strongly Powered by AbleSci AI