流体衰减反转恢复
医学
减法
核医学
脑活检
对比度(视觉)
淋巴瘤
活检
放射科
磁共振成像
病理
物理
数学
算术
光学
作者
Yoon Chul Lee,Sang‐il Suh,Inseon Ryoo,Hyena Jung,Leehi Joo
标识
DOI:10.1016/j.ejrad.2022.110490
摘要
The purpose of this retrospective study was to report and analyze the image findings of contrast-enhanced fluid-attenuated inversion recovery (CE-FLAIR) sequence of lymphoma in the brain.Thirty-two immunocompetent patients with biopsy-proven diffuse large B-cell type lymphoma in the brain were evaluated with pre-treatment MRI examinations from August 2014 to April 2020. As stereotactic studies on the day of biopsy, FLAIR and T1-weighted axial images were acquired in 2 mm thickness, before and after administrating gadolinium-based contrast agents, with 3.0 Tesla MR machines. Respective subtraction images were also obtained for both CE-FLAIR and contrast-enhanced T1-wieghted image (CE-T1WI) sequences. The imaging findings, especially the enhancement pattern on CE-FLAIR sequence, were analyzed qualitatively and quantitatively, using semi-automatic segmentation.On CE-FLAIR images, brain lymphomas were poorly enhanced, while showing peripheral rim enhancement (54 of 58 lesions, 93.1 %) and central enhancing foci (40 of 58 lesions, 69.0 %). Seventy percent of central enhancing foci were correlated to areas with low signal intensity on CE-T1WI. In quantitative analysis, the mean signal intensity of CE-T1WI subtraction was 490.44 and that of FLAIR subtraction was 206.13. The standard deviation of all signal intensity values in CE-T1WI subtraction sequence was 143.45, while that of CE-FLAIR subtraction sequence was 118.41.On CE-FLAIR, brain lymphomas showed relatively poor and homogeneous enhancement, when compared to CE-T1WI. Most brain lymphomas displayed peripheral rim enhancement and central enhancing foci.
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