Acute necrotizing encephalopathy caused by SARS-CoV-2 in a child

Neurological manifestations in patients with coronavirus disease 2019 (COVID-19) including anosmia, ageusia, meningoencephalitis, encephalopathy, cerebrovascular disease, Guillain-Barré syndrome, acute disseminated encephalomyelitis, and seizures, have been reported.1 Acute necrotizing encephalopathy (ANE) is a rare brain disease characterized by multiple necrotic lesions with a symmetric distribution. ANE has been reported in adults and children with COVID-19.2–4 The Omicron variant surged in Taiwan in April 2022, and fatal neurological diseases emerged in children.