登革热
芳基
吡啶
载体(分子生物学)
化学
组合化学
立体化学
病毒学
毒理
有机化学
生物
生物化学
烷基
基因
重组DNA
作者
Pamela Pal,Sayanti Show,S. Das,Sayantika Bhakta,Swarupa Mondal,Priya Roy,Tapas Ghosh,Raj Kumar Nandi
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2024-01-22
摘要
Abstract We report a convergent synthesis of heteroaryl/aryl-annulated pyridine and quinoline derivatives by a metal-free Povarov reaction. para-Toluene sulfonic acid was used as the catalyst in this reaction, which produced the products in good yields from the corresponding aromatic amines and ethyl vinyl ether. A pyridocoumarin and a pyridopyrimidine product were evaluated for their mosquito larvicidal activity against the third instar larvae of the dengue vector mosquito Aedes aegypti. Examination of morphological changes in the larvae showed damage to the target body part after treatment with both the pyridocoumarin and pyridopyrimidine products at the LC50 concentrations.
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