化学
荧光
核酸
石墨
波长
核糖核酸
碳纤维
氮气
纳米技术
红外线的
生物物理学
光电子学
光学
有机化学
生物化学
基因
生物
复合材料
复合数
材料科学
物理
作者
Ning Xu,Haoying Ge,Jiazhu Zheng,Wen Sun,Jianjun Du,Jiangli Fan,Xiaojun Peng
标识
DOI:10.1021/acs.analchem.3c05670
摘要
Nucleic acid is one of the most important substances in organisms, and its dynamic changes are closely related to physiological processes. Nucleic acid labeling is conducive to providing important information for the early diagnosis and treatment of pathophysiological processes. Here, we utilized the transfer mechanism between carbon sources and CDs to synthesize wavelength-adjustable N-CDs for the nucleic acid image. Along with the increased graphite nitrogen (from 10.6 to 30.1%) gradually by the precise design of the nitrogen structure in carbon sources (e.g., primary amines, secondary amines, tertiary amines, and liking graphite-nitrogen), the energy gap of CDs reduced, resulting in adjustable wavelength from visible to near-infrared range (from 461 nm/527 nm to 650 nm/676 nm). Furthermore, N-CDs exhibited a selective affinity for nucleic acids, especially RNA. Therefore, N-CDs support an efficient platform for real-time tracking of RNA dynamic changes in cells.
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