再生（生物学）
Wnt信号通路
硫氧化物9
纤维化
细胞生物学
癌症研究
生物
医学
病理
遗传学
信号转导
基因表达
基因
作者
Shikhar Aggarwal,Zhanxiang Wang,David Rincon Fernandez Pacheco,Anna Maria Rinaldi,Alex Rajewski,Jasper Callemeyn,Elisabet Van Loon,Baptiste Lamarthée,Ambart E. Covarrubias,Jean Hou,M Yamashita,Haruhiko Akiyama,S. Ananth Karumanchi,Clive N. Svendsen,Paul W. Noble,Stanley C. Jordan,Joshua J. Breunig,Maarten Naesens,Pietro E. Cippà,Sanjeev Kumar
出处
期刊：Science
[American Association for the Advancement of Science]
日期：2024-02-22
卷期号：383 (6685)
被引量：31
标识
DOI：10.1126/science.add6371
摘要
The steps governing healing with or without fibrosis within the same microenvironment are unclear. After acute kidney injury (AKI), injured proximal tubular epithelial cells activate SOX9 for self-restoration. Using a multimodal approach for a head-to-head comparison of injury-induced SOX9 lineages, we identified a dynamic SOX9 switch in repairing epithelia. Lineages that regenerated epithelia silenced SOX9 and healed without fibrosis (SOX9
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