Efficiently Synthesized, Multifunctional Recyclable Hydrogel for Accelerated Wound Healing

Infections from bacteria and fungi, along with ongoing inflammation in chronic wounds, can prolong the healing process and potentially lead to cancers. Hydrogel dressings, when used as wet dressings, have shown promise in accelerating wound healing and minimizing further wound damage. We developed a hydrogel dressing incorporating natural small molecules, specifically Lipoic acid and Magnolol, to reduce reliance on hazardous organic solvents and heavy metal ions. This development employed an environmentally friendly and sustainable approach, contributing to energy conservation. The fabricated hydrogel underwent testing to evaluate its injectability, antioxidant properties, sustained drug release, in vitro degradability, and effectiveness in healing infected wounds. Notably, the hydrogel exhibited low cytotoxicity, enhancing cell proliferation at concentrations below 62.5 mg/L. It also demonstrated anti-inflammatory and antifungal properties, alongside substantial antibacterial qualities that facilitate the healing of bacterial-infected wounds. Furthermore, the material's recyclability has been established. Multiple studies have validated the efficacy of this multifunctional, recycled hydrogel, underscoring its potential as a sustainable dressing for treating infected wounds.