法尼甾体X受体
G蛋白偶联胆汁酸受体
原发性胆汁性肝硬化
胆汁酸
自身免疫性肝炎
免疫系统
原发性硬化性胆管炎
炎症
获得性免疫系统
背景(考古学)
受体
肝病
先天免疫系统
肝硬化
免疫学
医学
生物
肝炎
内科学
核受体
疾病
生物化学
古生物学
转录因子
基因
作者
Tianhao Zhou,Abbas Ismail,Heather Francis
出处
期刊:Cells
[MDPI AG]
日期:2023-11-29
卷期号:12 (23): 2725-2725
被引量:1
标识
DOI:10.3390/cells12232725
摘要
As bile acids not solely play an essential role in nutrition absorption, but also in regulating metabolic functions as well as immune response, bile acids and their signaling pathways are increasingly acknowledged as potential therapeutic targets in the context of chronic liver diseases. Bile acid receptors such as G protein bile acid-activated receptor 1 and farnesoid X receptor are expressed in different immune cells engaged in innate immunity. Recently, a series of studies have revealed distinct functions of bile acids and bile acid receptors within the adaptive immune system. In addition, a variety of molecules targeting bile acid receptors and transporters are currently in advanced stages of clinical development. Autoimmune liver diseases including conditions like primary biliary cholangitis, primary sclerosing cholangitis, and autoimmune hepatitis can lead to chronic inflammation, fibrosis, and even cirrhosis and liver failure. In this review, we focus on the role of bile acids in the inflammatory aspects of autoimmune liver diseases.
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