硼氢化
对映选择合成
铜
部分
催化作用
区域选择性
化学
光学活性
组合化学
立体化学
有机化学
作者
Yuki Kojima,Yuji Nishii,Koji Hirano
标识
DOI:10.1002/anie.202403337
摘要
A synthetic method for preparation of optically active trifluoromethylthio (SCF3) compounds by a copper-catalyzed regio- and enantioselective hydroboration of 1-trifluoromethylthioalkenes with H-Bpin has been developed. The enantioselective hydrocupration of an in situ generated CuH species and subsequent boration reaction generate a chiral SCF3-contaning alkylboronate, of which Bpin moiety can be further transformed to deliver various optically active SCF3 molecules. Computational studies suggest that the SCF3 group successfully controls the regioselectivity in the reaction.
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