Study effect of poisoning lead acetate on hepatocyte and (GoT , GpT) Enzymes in albino mice

The aim of the search is study effect of poisoning doses of lead acetate on hepatocyte and Enzymes of GoT & GpT in mice exposed to poisoning lead acetate . This study was done on 40 mice ( male & female ) divide into four groups with evenly numbers , ten mice in each group Three groups received drinking water contained respectively , ( 0.5 ,1.0 ,1.5 mg) of lead acetate for one month while the four group was received drinking water only served as control group .The enzymatic study showed that significant difference (P<0.05) were found in the levels of GoT & GpT in mice groups treated with lead acetated compared with control group. The section of histological study showed necrosis and fibrosis in hepatocyte in mice treated with lead acetate compared with control group. The clinical signs of animal were recorded continuously in all time of study . The main signs were sluggishness , restlessness and dyspnea in mice groups treated with lead acetated compared with control group .The severity of sign was increased with time of exposure .It is concluded that exposure to lead acetate induce several enzymatic and histological changes .