化学
光热治疗
光动力疗法
酞菁
两亲性
PEG比率
单线态氧
荧光
光敏剂
纳米技术
纳米颗粒
光化学
聚合物
有机化学
材料科学
共聚物
光学
氧气
财务
经济
物理
作者
Ke Zheng,Xinxin Liu,Mengyuan Li,Shangmei Zhou,Caifeng Ding
标识
DOI:10.1021/acs.analchem.2c03128
摘要
Switchable theranostics are of great interest for accurate tumor imaging and targeted therapy. Here, we develop smart engineering to construct nanostructured phthalocyanines self-assembled by amphiphilic zinc phthalocyanines (ZnPcs) and hydrophobic copper phthalocyanines (CuPcs) (ZnPc(PEG)5:CuPc-N, where ZnPc(PEG)5 is monosubstituted ZnPcs with pentaethylene glycol as the substituent). The fluorescence and reactive oxygen species generation of ZnPc(PEG)5:CuPc-N can be triggered depending on the membrane of the tumor cells for the imaging and photoactivities. Concerning the stability in blood circulation, the surface of the nanocomplex is coated with polydopamine, which responds to the tumor acidic microenvironment. ZnPc(PEG)5 and CuPc focus on photodynamic and photothermal properties, respectively, and can be stimulated by a single laser beam, endowing ZnPc(PEG)5:CuPc-N a combined antitumor effect from evaluations both in vitro and in vivo. In our study, the mechanism of switchable theranostics, the strategy of combined photodynamic and photothermal therapy, and the smart nanoengineering technology of phthalocyanines with poor water solubility can be applied to other phthalocyanines or phthalocyanine-like phototherapy agents.
科研通智能强力驱动
Strongly Powered by AbleSci AI