SH-SY5Y型
萜类
小桶
神经保护
基因本体论
立体化学
化学
药理学
传统医学
生物
基因
生物化学
医学
基因表达
细胞培养
遗传学
神经母细胞瘤
作者
Ye Chang,Li‐Li Lou,Xin Zhang,Jiao-Yang Hou,Guo‐Dong Yao,Xiao‐Xiao Huang,Shao‐Jiang Song,Bin Lin,Ming Bai
出处
期刊:Fitoterapia
[Elsevier]
日期:2022-11-01
卷期号:163: 105346-105346
被引量:5
标识
DOI:10.1016/j.fitote.2022.105346
摘要
Four new terpenoids, solanoids F - I (1-4), together with eleven known compounds (5-15), were isolated from the whole herb of Solanum lyratum. The chemical structures were characterized by spectroscopic techniques, and electronic circular dichroism (ECD) data analysis was adopted to confirm the absolute configurations of 1-4. Compounds 1-6, 8 and 12-15 exhibited neuroprotective effects against H2O2-induced oxidative damage of human SH-SY5Y cells. Additionally, this study also combined Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses to explore the potential targets and signaling pathways of active terpenoids components in intervening Alzheimer's disease (AD).
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