Lactate‐Modulating Nanoreactors Facilitate Self‐Amplifying Pyroptosis and the cGAS‐STING Cascade for Potentiated Catalytic‐Immunotherapy

-lipiodol emulsion demonstrates exceptional therapeutic performance in a rat orthotopic hepatocellular carcinoma model when integrated with transcatheter arterial embolization (TAE) or transarterial chemoembolization (TACE) treatments. Therefore, the adverse factor lactate is ingeniously utilized to increase the activation of pyroptosis-STING via a cascade reaction, ultimately achieving superior tumor control.