光动力疗法
癌症
活性氧
免疫疗法
生物相容性
癌细胞
癌症免疫疗法
肿瘤微环境
免疫系统
癌症研究
细胞毒性
化学
免疫原性细胞死亡
脂质体
药物输送
细胞
癌症治疗
跨膜蛋白
光敏剂
信号转导
作者
Jiangang Mei,Weilun Pan,Bo Li,Mingzhen Zhong,Xiudong Shi,Yanfang Cheng,Bodeng Wu,Qi Xiu,Yicong Xue,Bo Situ,Lei Zheng
出处
期刊:ACS Nano
[American Chemical Society]
日期:2025-09-30
卷期号:19 (40): 35933-35950
被引量:7
标识
DOI:10.1021/acsnano.5c13350
摘要
Photodynamic immunotherapy has emerged as a promising cancer therapeutic strategy, yet its efficacy is crucially hindered by the hypoxic and immunosuppressive tumor microenvironment (TME). Herein, we present a bioinspired nanoplatform that leverages the natural photosynthetic capabilities of spinach-derived nanovesicles (SDNV) for light-excited oxygen evolution to address this critical challenge. SDNV is engineered to encapsulate aggregation-induced emission luminogens (AIEgen), forming AIE@SDNV nanoparticles with excellent biocompatibility and transmembrane permeability. Upon irradiation, SDNV generates substantial oxygen as a substance for AIEgen to produce reactive oxygen species, thus improving the photodynamic efficacy by triggering severe cellular lipid peroxidation and calcium ion imbalance. This leads to potent tumor cell destruction and immunogenic cell death. Subsequently, significant release of damage-associated molecular patterns from tumor cells enhances systemic antitumor immunity via the cGAS-STING signaling pathway and activates immune responses within the TME. Moreover, SDNV enables precise AIEgen delivery and prolonged tumor retention. Simultaneously, AIE@SDNV-mediated photoimmunotherapy effectively suppresses both primary and distant tumors in a bilateral tumor model. This study provides a promising strategy for efficiently delivering a therapeutic agent, improving hypoxia-restricted photodynamic therapy, and reversing the immunosuppressive TME, thereby achieving potentiated antitumor efficacy and highlighting the potential of plant-derived nanovesicles in advancing cancer nanomedicine.
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