生物
内部收益率3
先天免疫系统
表观遗传学
免疫系统
干扰素
DNA甲基化
免疫
病毒复制
干扰素调节因子
病毒学
钻机-I
机制(生物学)
调节器
免疫学
病毒
遗传学
基因
基因表达
哲学
认识论
作者
Mengdong Wang,Jingjing Song,Chao Gao,Cuilian Yu,Chao Qin,Yue Lang,Aotian Xu,Yun Liu,Wenhai Feng,Jun Tang,Rui Zhang
摘要
Alphaherpesviruses can establish lifelong infections and cause many diseases in humans and animals, which rely partly on their interaction with IFN-mediated innate immune response. Using alphaherpesviruses PRV and HSV-1 as models, we identified an essential role of DNA methylation regulator UHRF1 in IFN-mediated immunity against virus replication, which unravels a novel mechanism employed by epigenetic factor to control IFN-mediated antiviral immune response and highlight UHRF1, which might be a potential target for antiviral drug development.
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