产热
褐色脂肪组织
内分泌学
内科学
白色脂肪组织
生物
产热素
PRDM16
脂肪组织
腺苷酸激酶
脂肪细胞
医学
受体
作者
Jie Liu,Limin Wei,Ting Chen,Huan Wang,Junyi Luo,Xingping Chen,Qingyan Jiang,Qianyun Xi,Jiajie Sun,Lin Zhang,Yongliang Zhang
出处
期刊:Endocrinology
[The Endocrine Society]
日期:2023-07-24
卷期号:164 (9)
被引量:2
标识
DOI:10.1210/endocr/bqad114
摘要
Abstract Excessive energy intake is the main cause of obesity, and stimulation of brown adipose tissue (BAT) and white adipose tissue (WAT) thermogenesis has emerged as an attractive tool for antiobesity. Although miR-143 has been reported to be associated with BAT thermogenesis, its role remains unclear. Here, we found that miR-143 had highest expression in adipose tissue, especially in BAT. During short-term cold exposure or CL316,243 was injected, miR-143 was markedly downregulated in BAT and subcutaneous WAT (scWAT). Moreover, knockout (KO) of miR-143 increases the body temperature of mice upon cold exposure, which may be due to the increased thermogenesis of BAT and scWAT. More importantly, supplementation of miR-143 in BAT of KO mice can inhibit the increase in body temperature in KO mice. Mechanistically, spleen tyrosine kinase was revealed for the first time as a new target of miR-143, and deletion of miR-143 facilitates fatty acid uptake in BAT. In addition, we found that brown adipocytes can promote fat mobilization of white adipocytes, and miR-143 may participate in this process. Meanwhile, we demonstrate that inactivation of adenylate cyclase 9 (AC9) in BAT inhibits thermogenesis through AC9–PKA–AMPK–CREB–UCP1 signaling pathway. Overall, our results reveal a novel function of miR-143 on thermogenesis, and a new functional link of the BAT and WAT.
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