Cutaneous toxicity of CAR T‐cell therapy: Case report of a bullous life‐threatening reaction

Journal of the European Academy of Dermatology and VenereologyVolume 37, Issue 6 p. e729-e731 LETTER TO THE EDITOR Cutaneous toxicity of CAR T-cell therapy: Case report of a bullous life-threatening reaction Giovanni Fiorillo, Corresponding Author Giovanni Fiorillo [email protected] orcid.org/0000-0002-3089-4362 Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy Correspondence Giovanni Fiorillo, Dermatology Unit, IRCCS Humanitas Research Hospital, 20089 Milan, Italy. Email: [email protected]Search for more papers by this authorFrancesco Toso, Francesco Toso Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorAndrea Cortese, Andrea Cortese orcid.org/0000-0001-9500-444X Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorFrancesco Piscazzi, Francesco Piscazzi Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorAlessandra Bressan, Alessandra Bressan Department of Biomedical Sciences, Humanitas University, Milan, Italy Pathology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorStefania Bramanti, Stefania Bramanti Department of Oncology and Hematology, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorSofia Manara, Sofia Manara Pathology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorAlessandra Narcisi, Alessandra Narcisi Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorAntonio Costanzo, Antonio Costanzo orcid.org/0000-0001-9697-2557 Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorMario Valenti, Mario Valenti Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this author Giovanni Fiorillo, Corresponding Author Giovanni Fiorillo [email protected] orcid.org/0000-0002-3089-4362 Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, Italy Correspondence Giovanni Fiorillo, Dermatology Unit, IRCCS Humanitas Research Hospital, 20089 Milan, Italy. Email: [email protected]Search for more papers by this authorFrancesco Toso, Francesco Toso Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorAndrea Cortese, Andrea Cortese orcid.org/0000-0001-9500-444X Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorFrancesco Piscazzi, Francesco Piscazzi Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorAlessandra Bressan, Alessandra Bressan Department of Biomedical Sciences, Humanitas University, Milan, Italy Pathology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorStefania Bramanti, Stefania Bramanti Department of Oncology and Hematology, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorSofia Manara, Sofia Manara Pathology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorAlessandra Narcisi, Alessandra Narcisi Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorAntonio Costanzo, Antonio Costanzo orcid.org/0000-0001-9697-2557 Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this authorMario Valenti, Mario Valenti Department of Biomedical Sciences, Humanitas University, Milan, Italy Dermatology Unit, IRCCS Humanitas Research Hospital, Milan, ItalySearch for more papers by this author First published: 20 January 2023 https://doi.org/10.1111/jdv.18892Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Rubin CB, Elenitsas R, Taylor L, Lacey SF, Kulikovskaya I, Gupta M, et al. Evaluating the skin in patients undergoing chimeric antigen receptor modified T-cell therapy. J Am Acad Dermatol. 2016; 75(5): 1054–7. https://doi.org/10.1016/j.jaad.2016.06.062 10.1016/j.jaad.2016.06.062 PubMedWeb of Science®Google Scholar 2Hu Y, Zheng W, Qiao J, Cui Q, Zhu Y, Chang AH, et al. Bullous and exanthematous lesions associated with chimeric antigen receptor T-cell therapy in a patient with diffuse large B-cell lymphoma. JAMA Dermatol. 2020; 156(9): 1026–8. https://doi.org/10.1001/jamadermatol.2020.0636 10.1001/jamadermatol.2020.0636 PubMedWeb of Science®Google Scholar 3Sassolas B, Haddad C, Mockenhaupt M, Dunant A, Liss Y, Bork K, et al. 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