材料科学
拉曼光谱
拉曼散射
结块
分子
纳米技术
化学工程
微流控
金属
化学
复合材料
有机化学
光学
物理
工程类
冶金
作者
Dong Jae Kim,Tae Yoon Jeon,Sung Gyu Park,Hyo Kyung Han,Sang Hyuk Im,Dong Ho Kim,Shin‐Hyun Kim
出处
期刊:Small
[Wiley]
日期:2017-05-02
卷期号:13 (23)
被引量:25
标识
DOI:10.1002/smll.201604048
摘要
Surface-enhanced Raman scattering (SERS) is a promising technique for molecular analysis as the molecular fingerprints (Raman spectra) are amplified to detectable levels compared with common spectroscopy. Metal nanostructures localize electromagnetic field on their surfaces, which can lead to dramatic increase of Raman intensity of molecules adsorbed. However, the metal surfaces are prone to contamination, thereby requiring pretreatment of samples to remove adhesive molecules. To avoid the pretreatment and potentially achieve point-of-care (POC) analysis, we have developed SERS-active microgels using the droplet-microfluidic system. As the microgels are composed of water-swollen network with consistent mesh size, they selectively allow diffusion of molecules smaller than the mesh, thereby excluding large adhesives. To render the microgels highly SERS-active, we destabilize silver nanocubes to form agglomerates, which are embedded in the matrix of microgels. The nanogaps in the agglomerates provide high sensitivity in Raman measurement and size-selective permeability of the microgel matrix obviates the pretreatment of samples. To validate the functions, we demonstrate the direct detection of Aspirin dissolved in whole blood without any pretreatment.
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