化学
哌嗪
催化作用
位阻效应
芳基
组合化学
溶剂
有机化学
烷基
作者
Sean W. Reilly,Robert H. Mach
出处
期刊:Organic Letters
[American Chemical Society]
日期:2016-10-13
卷期号:18 (20): 5272-5275
被引量:40
标识
DOI:10.1021/acs.orglett.6b02591
摘要
A facile Pd-catalyzed methodology providing an efficient synthetic route to biologically relevant arylpiperazines under aerobic conditions is reported. Electron donating and sterically hindered aryl chlorides were aminated to afford yields up to 97%, with examples using piperazine as solvent, illustrating an ecofriendly, cost-effective synthesis of these privileged structures.
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